Info Navigator: A visualization tool for document searching and browsing

In this paper we investigate the retrieval performance of monophonic and polyphonic queries made on a polyphonic music database. We extend the n-gram approach for full-music indexing of monophonic music data to polyphonic music using both rhythm and pitch information. We define an experimental framework for a comparative and fault-tolerance study of various n-gramming strategies and encoding levels. For monophonic queries, we focus in particular on query-by-humming systems, and for polyphonic queries on query-by-example. Error models addressed in several studies are surveyed for the fault-tolerance study. Our experiments show that different n-gramming strategies and encoding precision differ widely in their effectiveness. We present the results of our study on a collection of 6366 polyphonic MIDI-encoded music pieces

NNk networks and automated annotation for browsing large image collections from the world wide web

This paper outlines a system for searching and browsing 1.14 million images from the World Wide Web (WWW) based on their visual content. At the heart of the system lies an automatically constructed network of images that can be navigated quickly by following its edges. The browsing experience is enhanced in a number of ways including multidimensional scaling of the graph neighbourhood for display purposes, Markov clustering of the image network to provide summaries of its content, and automated annotation of the images to allow users to access the network through text queries

Chaotic root-finding for a small class of polynomials

In this paper we present a new closed-form solution to a chaotic difference equation, $y_{n+1} = a_2 y_{n}^2 + a_1 y_{n} + a_0$ with coefficient $a_0 = (a_1 - 4)(a_1 + 2) / (4 a_2)$, and using this solution, show how corresponding exact roots to a special set of related polynomials of order $2^p, p \in \mathbb{N}$ with two independent parameters can be generated, for any $p$

Do “attractive things work better”? An exploration of search tool visualisations

A study was conducted to explore associations that may exist between user perceptions of aesthetics and usability in an attempt to validate Norman’s assertion that “attractive things work better”. Participants were run in a semi between-subjects design study. Judgements for aesthetics and usability were elicited prior to and after each test run with a record kept of performance. Pre-use and post-use measures indicated strong relations between judgements of aesthetics and usability, but an association was not found between aesthetics and performance, leading us to conclude that “attractive things are perceived to work better” though attractive systems may not work any better than unattractive systems. These results resemble past research and partly support the work of Norman proposing that valued aesthetics lead to a positive affective response, which opens the mind to creative thinking altering judgements made but not actual behaviour. The findings stress the importance of aesthetics in HCI and design, as an influential factor on perceptions of usability, which in turn influence higher order decisions

Cross-lingual searching and visualization for greek and latin and old norse texts

We explore approaches to multi--lingual information retrieval for Greek, Latin, and Old Norse texts and an innovative visualization facility for the results

Titin-truncating variants affect heart function in disease cohorts and the general population

Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encountered in ~1% of the general population, where they may be silent, perhaps reflecting allelic factors. To better understand TTNtv, we integrated TTN allelic series, cardiac imaging and genomic data in humans and studied rat models with disparate TTNtv. In patients with DCM, TTNtv throughout titin were significantly associated with DCM. Ribosomal profiling in rat showed the translational footprint of premature stop codons in Ttn, TTNtv-position-independent nonsense-mediated degradation of the mutant allele and a signature of perturbed cardiac metabolism. Heart physiology in rats with TTNtv was unremarkable at baseline but became impaired during cardiac stress. In healthy humans, machine-learning-based analysis of high-resolution cardiac imaging showed TTNtv to be associated with eccentric cardiac remodeling. These data show that TTNtv have molecular and physiological effects on the heart across species, with a continuum of expressivity in health and disease

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Interaction models and relevance feedback in image retrieval

Human-computer interaction is increasingly recognised to be an indispensable component of image retrieval systems. A typical form of interaction is that of relevance feedback whereby users supply relevance information on the retrieved images. This information can subsequently be used to optimise retrieval parameters. The first part of the chapter provides a comprehensive review of existing relevance feedback techniques and also discusses a number of limitations that can be addressed more successfully in a browsing framework. Browsing models form the focus of the second part of this chapter where we will evaluate the merit of hierarchical structures and networks for interactive image search. This exposition aims to provide enough detail to enable the practitioner to implement many of the techniques and to find numerous pointers to the relevant literature otherwise